Released on: December 14, 2007, 10:47 am

Press Release Author: ANAVEX LIFE SCIENCES

Industry: Biotech

Press Release Summary: Results in epilepsy animal models demonstrate that ANAVEX
2-73 and its active metabolite ANAVEX 19-144 have potent anticonvulsant,
anti-amnesic and neuroprotective properties

Press Release Body: Results in epilepsy animal models demonstrate that ANAVEX 2-73
and its active metabolite ANAVEX 19-144 have potent anticonvulsant, anti-amnesic and
neuroprotective properties
GENEVA, Switzerland, Dec. 6 /PRNewswire-FirstCall/ - Anavex Life Sciences Corp.
(\"ANAVEX\") (OTCBB: AVXL) today announced promising developments with ANAVEX 2-73 and
ANAVEX 19-144, the company\'s lead drug candidates to treat epilepsy. During recent
pre-clinical animal studies, ANAVEX 2-73 and ANAVEX 19-144 demonstrated significant
anticonvulsant, anti-amnesic, neuroprotective and anti-depressant properties.
These activities involve muscarinic and sigma-1 receptor components, which is
significant because it indicates a novel mechanism of action. Pioneered by ANAVEX,
Sigma-1 receptors are a fairly new class of receptors -- molecules within a cell or
on a cell surface to which substances (drugs or hormones) selectively bind, causing
a change in the activity of the cell.
\"Currently, there are no drugs available that truly control epilepsy or prevent
epileptogenesis, a process that causes long-term tissue and cell damage as well as
biochemical and physiological alterations to the brain. These alterations cause
seizures and are linked with the progressive deterioration or death of the body\'s
nerve cells,\" said Dr. Kontzalis, Chief Executive Officer for ANAVEX. \"In addition,
the drugs to treat epilepsy that are on the market today are often associated with
cognitive, psychotic and memory problems. As such, we believe that novel drugs like
ANAVEX 2-73 and ANAVEX 19-144, which have anti-epileptogenic, neuroprotective and
anti-amnesic properties, are certain to have a major impact on the anti-epileptic
drug market around the world.\"
Anticonvulsive properties were tested in epilepsy animal models with maximum
electroshock (MES)- and pentylenetetrazole (PTZ)-induced generalized convulsions. In
90-100% of the treated animals versus the control group, both ANAVEX 2-73 and ANAVEX
19-144 exhibited extremely significant anticonvulsive action by providing almost
complete protection from tonic seizures. This was accomplished without causing any
memory deficits (amnesic effect) or mood disturbances (depression). Memory deficits
and depressive phenomena are usually observed with the anti-epileptic drugs
available today.
In PTZ-induced convulsions it was further observed that ANAVEX 19-144 is able to
significantly prolong life during a seizure. Control-group animals died after three
minutes and two seconds, while animals that received ANAVEX 19-144 were still alive
after 50 minutes.
The pre-clinical study tested the anti-amnesic properties of ANAVEX 2-73 and ANAVEX
19-144 on mice, which were then submitted to short- and long-term memory tests,
spontaneous alternation and passive avoidance respectively. Testing was conducted in
pharmacological and pathological mouse models of amnesia. When the epilepsy drug
candidates were administered to the mice, the compound dose reversed the learning
deficits induced by the drugs scopolamine and dizocilpine and by the administration
of amyloid beta peptide. The effects of ANAVEX 2-73 were linked to action at
muscarinic and sigma-1 receptor sites because they were blocked by pre-injection of
the sigma-1 receptor antagonist BD 1047.




The neuroprotective properties of ANAVEX 2-73 and ANAVEX 19-144 were studied in a
non-transgenic mouse model of Alzheimer\'s disease. Central injection of amyloid beta
peptide in mouse brains is known to induce histological and biochemical changes,
oxidative stress and learning deficits within seven days. ANAVEX 2-73 or ANAVEX
19-144 administered once, either orally or by injection, prevented the appearance of
amyloid beta peptide-induced learning or memory deficits. It also prevented
oxidative stress, which damages and destroys cells, and nerve cell loss in sensitive
areas of the brain that regulate learning, emotion and memory. In addition, the
neuroprotective properties of ANAVEX 19-144 have been demonstrated, in a transient
focal cerebral ischemia mouse model, to reduce the infarct area after ischemia by
28%.
The neuroprotective properties of ANAVEX 2-73 and ANAVEX 19-144 have been observed
at very low doses (0.1-0.3 mg/kg). These doses are far below the levels that induce
cholinergic- or sigma 1 receptor-related side effects, verifying the anticipated
enhanced safety profile of the ANAVEX epilepsy drug candidates.
\"We are confident that we have achieved proof-of-concept status for ANAVEX 2-73 and
ANAVEX 19-144,\" said Dr. Vamvakides, Chief Scientific Officer of ANAVEX. \"These
latest results provide strong evidence as to the promise and potential of our
epilepsy drug candidates, which have anti-epileptogenic action as well as an optimal
efficacy and safety profile.\"
Ongoing pre-clinical studies, which are being conducted in collaboration with
Universite Montpellier in France, are scheduled for completion by the end of May
2008.
Published results were presented at the Neuroscience 2007 conference in San Diego,
California, and are available at http://www.anavex.com/publications.html.
About Epilepsy
Epilepsy is a term used for recurring seizure disorder, a condition that is
characterized by the tendency for an individual to have repeated nervous seizures
(interruption of normal brain activity). In 2004, the prevalence of epilepsy was
estimated to be approximately six million people across the seven major
pharmaceutical markets (France, Germany, Italy, Spain, UK, USA and Japan). By 2015,
it is predicted that 6.4 million people will be living with epilepsy. Epilepsy is
currently treated with older traditional anti-epileptic drugs (AEDs) and
second-generation AEDs, with the former marketed before 1980, and the latter class
marketed in the early 1990s. Today\'s AEDs are only effective in treating disease
symptoms. Currently, between 70% and 80% of patients are successfully treated with
one of the more than 20 anti-epileptic drugs now available. However, 20-30% of
patients have either intractable or uncontrolled seizures, or have significant
adverse side effects due to their medication, highlighting the ongoing need for the
development of new anti-epileptic drugs with optimal risk/benefit profiles.
New drugs able to modify the onset of epilepsy (epileptogenesis) and progression of
the disease, which have a novel mode of action that combines anticonvulsant,
anti-amnesic, anti-depressant and neuroprotective properties as well as excellent
safety and low toxicity,
are needed and have blockbuster potential. ANAVEX is developing drug candidates
demonstrating the above properties.
About Sigma Receptors
Sigma receptors are a unique family of proteins, present mainly in the central
nervous system (CNS) but also in various peripheral tissues. The receptors are
classified in two subtypes: the sigma-1 and sigma-2. These subtypes are
distinguishable pharmacologically, functionally and by molecular size. Sigma-1
receptors have been cloned and shown to be distinct from any known receptor class.


In the CNS, they are involved in the modulation of neurotransmitter receptor
function and neurotransmitter release and response, as well as in memory and
learning processes, demonstrating potential neuroprotective and anti-amnesic
properties. The modulatory action and the implication of numerous cellular and
biochemical signaling pathways suggest possible sigma receptor involvement in many
neuronal processes, as well as in the pathophysiology of certain psychiatric
disorders including depression, schizophrenia, motor disturbances, neuropathic pain,
drug addiction and attention deficit disorders.
About ANAVEX
Anavex Life Sciences Corp. (www.anavex.com) is an emerging biopharmaceutical company
engaged in the discovery and development of novel drug targets for the treatment of
cancer and neurological diseases. The company\'s proprietary SIGMACEPTOR(TM)
Discovery Platform involves the rational drug design of compounds that fulfill
specific criteria based on unmet market needs and new scientific advances. Selected
drug candidates demonstrate high, non-exclusive affinity for sigma receptors, which
are involved in the modulation of multiple cellular biochemical signaling pathways.
ANAVEX\'s SIGMACEPTOR(TM)-N program involves the development of novel and original
drug candidates, targeting neurological and neurodegenerative diseases (Alzheimer\'s
disease, epilepsy, depression, etc.). The company\'s lead drug candidates exhibit
high, non-exclusive affinity for sigma receptors with strong evidence for
anti-amnesic, neuroprotective, anti-apoptotic, anti-oxidative, anti-inflammatory,
anti-convulsive, anti-depressant and anxiolytic properties.
ANAVEX SIGMACEPTOR(TM)-C program involves the development of novel and original drug
candidates targeting cancer. The company\'s lead drug candidates exhibit high,
non-exclusive affinity for sigma receptors with strong evidence for selective
pro-apoptotic, anti-metastatic and low toxicity properties in various types of solid
cancers such as colon, prostate, breast, lung, etc.
Forward-Looking Statements
This press release contains forward-looking statements for Anavex Life Sciences
Corp. that involves a number of risks and uncertainties. Actual events or results
may differ materially from those projected in any of such statements due to various
factors. Among other things, there can be no assurance that any of the Company\'s
development efforts relating to its product candidates, ANAVEX 2-73 & ANAVEX 19-144,
will be successful, or such product candidates will be successfully commercialized
or that ANAVEX 2-73 & ANAVEX 19-144 will have the potential to treat epilepsy or
other types of neurodegenerative diseases or that ANAVEX 2-73 & ANAVEX 19-144 will
provide clinically relevant advantages over other competitive compounds in
development. Other risks that affect forward-looking information contained in this
press release include the high degree of risk associated with drug development,
results of further research and development, the impact of competition and of
technological advances and other risks detailed to Anavex\'s SEC filings. Other than
as required by federal securities laws, we undertake no obligation to publicly
update or revise any of our forward-looking statements, whether as a result of
changed circumstances, new information, future events, or for any other reason
occurring after the date of this news release.




Web Site: http://www.anavex.com/press_release_2007_12_06.html

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